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Population control by  dsx gene-drive in mosquitoes

9/25/2018

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Today, researchers came again one step closer to using gene-drives for population control of pest species. In this case, Kyrou et al. targeted the highly conserved sexual differentiator, doublesex, using CRISPR/Cas9. They show that by disrupting the intron-exon boundary of the female-specific splice variant they could create intersexes that are sterile instead of healthy females. As they only targeted the female-splice variant, males were unaffected. However, it did require a homozygous mutation as one functional allele was still enough for normal female development. By creating a gene-drive targeting this specific site, they could spread this mutation quickly through the population, crashing it within a few generations.

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CLOSED: Postdoc position available in my lab!

9/1/2018

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Gene regulatory evolution in insect sexual dimorphism

Within my lab I'm looking for a highly motivated and skilled postdoc candidate, interested in curiosity-driven research who can work in a multidisciplinary team in a collaborative spirit. Your main task will be to identify the binding sites and target genes of the sexual differentiator, doublesex.

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For more background on the position, go to Available positions.

To apply for this position please go here. The deadline is September 23.
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NWO-Vidi grant  of 800.000 EUR received!

6/1/2018

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I'm super happy to announce that I have been awarded a NWO-Vidi grant of 800.000 EUR for five years to continue and further develop my research on the evolution of male-female phenotypic differences. To be more specific, I will look at the molecular basis of three sex-specific characteristics that have recently arisen in insects.

​For those of you interested in my proposal, you can download it here.

Within approximately two months I will be advertising two PhD projects and one Post-doc position. If you are highly motivated, conceptually strong with a background in molecular biology, biotechnology or related and interested in joining my team, keep an eye on the site or contact me.

Vidi is aimed at experienced researchers who have carried out successful research for a number of years after obtaining their PhDs. Together with Veni and Vici, Vidi is part of the NWO Talent Scheme. Researchers in the NWO Talent Scheme are free to submit their own subject for funding. NWO thus encourages curiosity-driven and innovative research. NWO selects researchers based on the quality of the researcher, the innovative character of the research, the expected scientific impact of the research proposal and the possibilities for knowledge use.

See NWO website for more information.
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CLOSED: Searching for 2 PhD candidates

2/23/2018

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CLOSED
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Are you interesting in working on the fore-front of biological control in a multidisciplinary project? Do you enjoy combining field work in greenhouses with experiments in the laboratory?

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Happy Darwin Day!

2/12/2018

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On the 12th of February it is International Darwin Day. A great day to remember what Charles Darwin did for Science in general and Biology in particular. Thanks to his research and dedication we have a much better understanding of why life is shaped as it is throughout history of time. 

And what better way to celebrate this with a parody done by the brilliant artist A Capella Science in which he explains in the most awesome way the field of Evolutionary Developmental Biology.

By the way, check out the other videos he's made on for example Gravitational Waves or the history of Exoplanets.

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Received ZonMW ETH grant for RENEW proposal

1/16/2018

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Just before Christmas I received news that my ZonMW Enabling Technologies Hotel proposal called RENEW: Resequencing Nasonia to Enhance its Workability is getting subsidized!

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First meeting of new NLSEB society!

1/11/2018

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Very soon the Netherlands Society for Evolutionary Biology will be a fact and we will celebrate this initiative with our first ever meeting on the 11th of April 2018 in Akousticum in Ede. 
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Environmental sex determination in a warming climate

1/9/2018

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Does climate change spell doom for sea turtles only because of the way they determine their sex?

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30 sec DNA extractions with a paper strip

1/6/2018

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Recently, scientists discovered by accident that a small strip of Whatman no. 1 paper can capture nucleic acids rapidly from a crude mixture containing ground up tissue in a lysis buffer. The paper strip can then be quickly washed without releasing the nucleic acid. After these steps, the paper strip retains enough nucleic acids to be dipped into a PCR reaction mixture and be used for amplification (Zou et al. 2017).

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CRISPR/Cas9 mouse engineered for easy genome editing

10/30/2014

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A new genome tool has just become a bit easier to use in the lab with the publication of a knock-in CRISPR/Cas9 mouse. This tool allows researchers to easily edit the genome in specific locations so they can study the effect of a gene knockdown or alteration. Already, researchers were able to use this technique in vitro but now, a mouse strain has been made that can take this CRISPR/Cas9 system to the next level.

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​Last updated: 20 May, 2022
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