Today, researchers came again one step closer to using gene-drives for population control of pest species. In this case, Kyrou et al. targeted the highly conserved sexual differentiator, doublesex, using CRISPR/Cas9. They show that by disrupting the intron-exon boundary of the female-specific splice variant they could create intersexes that are sterile instead of healthy females. As they only targeted the female-splice variant, males were unaffected. However, it did require a homozygous mutation as one functional allele was still enough for normal female development. By creating a gene-drive targeting this specific site, they could spread this mutation quickly through the population, crashing it within a few generations.
Gene regulatory evolution in insect sexual dimorphism
Within my lab I'm looking for a highly motivated and skilled postdoc candidate, interested in curiosity-driven research who can work in a multidisciplinary team in a collaborative spirit. Your main task will be to identify the binding sites and target genes of the sexual differentiator, doublesex.
For more background on the position, go to Available positions.
To apply for this position please go here. The deadline is September 23.